⒈重症急性胰腺炎

重症急性胰腺炎严重危害病人生命健康，常见诱因为胆道结石、酒精、高血脂等。常引起胰腺坏死、出血、胰周脓肿、假性囊肿、肠瘘、肠道梗阻以及心、肺、肾等器官功能障碍，死亡率极高。

本中心经过多年的研究和探索，在重症急性胰腺炎的治疗方面积累了极其丰富的经验。早期积极应用体液复苏，血滤、呼吸机辅助呼吸、器官功能保护、分阶段营养支持等现代治疗方法，后期根据患者的具体情况，包括有无胆道结石、胰腺周围组织坏死、感染、出血、假性囊肿以及胃肠道并发症等情况实施综合治疗，有效降低了重症急性胰腺炎患者的死亡率、使重症急性胰腺炎治疗成功率达到国内领先水平。

⒉胰腺及壶腹周围肿瘤、胆胰汇合部肿瘤

胰腺癌恶性程度高，早期诊断困难，其主要症状为腹痛、上腹不适、黄疸、消瘦、腰背痛等，易与胃肠道、肝胆等疾病混淆。由于症状不典型、发现晚，许多患者在诊断时已经丧失了根治性手术的机会，预后极差，国内外报道胰腺癌手术切除率仅为30%左右。本中心通过胰腺癌科学的术前评估和手术切除技术的改进，将胰腺癌的手术切除率提高到近70%。在国内率先开展胰腺癌的区域灌注化疗，提高药物对肿瘤的杀伤效应，减少毒副作用。并通过粒子植入实施内定向放射治疗等综合疗法有效提高胰腺癌的临床疗效，并且改善了晚期胰腺癌患者的生存质量。

⒊其他胰腺相关疾病

慢性胰腺炎常见原因为胆道结石、酒精、急性胰腺炎等，常表现为消化不良、脂肪泻、消瘦等，部分病人合并糖尿病。本中心通过多年的研究发现慢性胰腺炎患者的癌变率明显升高，可能为胰腺癌的癌前病变。针对此现象，通过改良的保留十二指肠的胰头切除手术即切除了病灶，降低了患者的癌变风险，同时保留了患者的脏器，有效改善了患者术后的生活质量。

胰腺常见的囊实性肿瘤包括胰腺囊实性假乳头状瘤、胰腺导管内乳头状瘤、浆液性囊腺瘤、粘液性囊腺瘤、胰腺神经内分泌肿瘤、炎性假瘤等。胰腺囊肿分为真性囊肿和假性囊肿。真性囊肿可为先天性、肿瘤性、潴留性或寄生虫性等。假性囊肿则由急、慢性胰腺炎、胰腺外伤等引起。胰腺囊实性肿瘤根据肿瘤的具体情况多需手术干预，囊肿易发生出血、破裂、感染、胰瘘、胃肠道梗阻等严重并发症需要及时手术治疗。 本中心结合术前影像学检查、术中活检等措施对胰腺囊实性肿瘤进行精确评估，针对不同类型、部位的肿瘤采取相应的治疗方法，如保留十二指肠的胰头切除术、保留脾脏的胰头尾切除术，在切除肿瘤的同时，最大限度的保留了正常的胰腺组织，改善了患者的生活质量。

科研项目及学术成果

胰腺外科科研实力强大，研究方向始终站在学科前沿。胰腺外科目前承担国家自然基金16项，十一五攻关子项目一项，卫生部临床重点专科项目一项，卫生部行业专项科研项目两项等部省级课题20余项，获得科研经费支持1500余万元。该中心在特殊类型胰腺炎独特病理生理机制、胰腺癌干细胞及分子生物学机制的深入研究，国家权威杂志发表科研论文500余篇，其中SCI收录78篇，被引用共1000余次，多项研究成果处于国内领先或达到国际先进水平。胰腺癌诊断评估与综合治疗抉择体系的临床与基础研究成果多次在国内外大型学术会议报告，并且在国内30余家大型综合性医院推广应用。举办国家级继续教育培训班，目前已培训学员3000余名。迄今为止，该中心已培养博士研究生50余名，硕士研究生100余名。同时也投入力量在胰腺移植、胰岛移植等方面作出了大胆尝试。鉴于该学科带头人王春友教授在该领域做出的杰出贡献，被授予美国外科医师协会会师，美国医师联盟外籍会员。

成果获奖：

1 胰腺癌诊断评估与综合治疗抉择体系的临床与基础研究 2012 湖北省科技进步奖 一等奖

2 胰腺癌诊断评估与综合治疗抉择体系的临床与基础研究 2012 武汉市科技进步奖 一等奖

3 降低重症急性胰腺炎死亡率的四个关键措施的推广应用 2010 湖北省科技成果推广奖 二等奖

4 重症急性胰腺炎的综合救治方案的系统化与细化研究 2005 教育部科技进步奖 二等奖

5 重症急性胰腺炎的综合救治方案的系统化与细化研究 2005 湖北省科技进步奖 一等奖

承担科研项目：

卫生部行业基金 胰腺癌早期诊断与综合治疗

卫生部行业基金 胰腺囊性肿瘤的诊断与规范化治疗

国家“十一五”科技支撑计划 胰腺癌综合治疗技术体系研究

卫生部重点学科研究基金 胰腺重症疾病诊疗技术规范建立

国家自然科学基金 胰腺癌干细胞分离、鉴定及其关键调控分子表达研究

国家自然科学基金 胰腺癌起源于胰腺导管细胞与骨髓间充质干细胞融合细胞的实验研究

国家自然科学基金 衰老调控因子SIRT1与K-ras对话在胰腺癌发生发展中的作用

国家自然科学基金 胰腺癌微环境内TLR4/9、HIF-1α表达及相互调控与肿瘤生物学行为关系的研究

国家自然科学基金 树突状细胞疫苗联合Foxp3 siRNA诱导抗胰腺癌干细胞免疫反应治疗胰腺癌的实验研究

国家自然科学基金 胰岛素通过PKB信号通路调控HIF-1α与胰腺癌局部浸润能力的关系 国家自然科学基金 低浓度二甲双胍选择性抑制胰腺癌干细胞增殖的机制及提高化疗疗效的实验研究

国家自然科学基金 细胞外微环境应力在肝细胞恶性转化中作用及其机制

国家自然科学基金 Toll样受体及其信号通路在肝缺血再灌注损伤中的作用

国家自然科学基金 H0320肝素对重症急性胰腺炎治疗作用的新认识——肝素干扰

国家自然科学基金 H1502聚ADP-核糖聚合酶1调控高迁移率族蛋白1细胞内定位的机制及意义研究

国家自然科学基金 H1511再认识高迁移率族蛋白1的促炎活性- - 高迁移率族蛋白1放大脂多糖炎症效应的细胞内、外机制研究

HMGB1/RAGE配受体结合的机制及意义研究发表SCI收录论文：

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23. Zhao G, Cui J, Qin Q, et al. Mechanical stiffness of liver tissues in relation to integrin beta1 expression may influence the development of hepatic cirrhosis and hepatocellular carcinoma. J Sur Oncl. 2010; 102 (5): 482-489.

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25. Gang Z, Qi Q, Jing C, Wang C. Measuring microenvironment mechanical stress of rat liver during diethylnitrosamine induced hepatocarcinogenesis by atomic force microscope. Micro Res Tech. 2009; 72 (9): 672-678.

26. Zhang J, Wang H, Xiao Q, Liang H, Li Z, Jiang C, Wu H, Zheng Q. Hyaluronic acid fragments evoke Kupffer cells via TLR4 signaling pathway. Sci China C Life Sci. 2009;52(2):147-54.

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28. Xiong J, Zhu S, Zhou Y, Wu H, Wang C. Regulation of omega-3 fish oil emulsion on the SIRS during the initial stage of severe acute pancreatitis. J Huazhong Univ Sci Technolog Med Sci. 2009;29(1):35-8.

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37. Wan CD, Wang CY, Liu T, Cheng R, Wang HB. Alleviation of ischemia/reperfusion injury in ob/ob mice by inhibiting UCP-2 expression in fatty liver. World J Gastroenterol. 2008;14(4):590-4.

38. Liu T, Wang CY, Gou SM, Wu HS, Xiong JX, Zhou J. PDX-1 expression and proliferation of duct epithelial cells after partial pancreatectomy in rats.World J Gastroenterol. 2008;14(6):925-30.

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44. Hu WG, Liu T, Xiong JX, Wang CY. Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells. Acta Pharmacol Sin. 2007;28(8):1224-1230.

45. Zhang W, Long Y, Zhang J, Wang CY. Modulatory effects of EPA and DHA on proliferation and apoptosis of pancreatic cancer cells. J Huazhong Univ Sci Technolog Med Sci. 2007; 27(5):547-50.

46. Liu T, Wang CY, Yu F, et al. In vitro pancreas duodenal homeobox-1 enhances the differentiation of pancreatic ductal epithelial cells into insulin-producing cells. World J Gastroenterol. 2007; 13(39):5232-5237.

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51. Wan C, Wang C, Liu T, Wang H, Yang Z. Experimental study on the cryopreservation of LLC-PK1 epithelial cells with hypoxic UW solution. J Huazhong Univ Sci Technolog Med Sci. 2007;27(4):426-8.

52. Wan C, Wang C, Liu T, Cheng R, Yang Z. Preparation and preservation of hypoxia UW solution. J Huazhong Univ Sci Technolog Med Sci. 2007;27(5):554-6.

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54. Li K, Tao J, Li T, Yu Z, Yang Z, Wu H, Xiong J, Wang C. Effect of antisense oligodeoxynucleotide of vascular endothelial growth factor C on lymphangiogenesis and angiogenesis of pancreatic cancer. J Huazhong Univ Sci Technolog Med Sci. 2007;27(1):51-3.

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65. Yin T, Wang C, Liu T, Zhao G, Zhou F. Implication of EMT induced by TGF-beta1 in pancreatic cancer. J Huazhong Univ Sci Technolog Med Sci. 2006;26(6):700-2.

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70. Lu P, Liu F, Yao Z, Wang CY, Chen DD, Tian Y, Zhang JH, Wu YH. Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury. Hepatobiliary Pancreat Dis Int. 2005;4(3):350-5.

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